Neural Stem Cells
Dr Verdon Taylor - Principle Investigator
We are addressing the molecular mechanisms that control somatic stem cell maintenance and fate. We focus on neural stem cells of the embryonic and adult brain in an attempt to elucidate the niche signals that regulate self-renewal, differentiation and regeneration. Based on the putative link between neural stem/progenitors cells and malignant brain tumour initiation and progression, we also address possible niche signals within gliomas and their role in tumour formation.
We envisage that understanding the niche and neural and glioma stem cell maintenance will reveal exciting and novel means for regenerative therapy and treatment of brain tumours.
Group members:
Dr Claudio Giachino
Postdoctoral fellow
Addresses the molecular mechanisms controlling neural stem cell maintenance in the adult brain. This involves using genetic tools to identify and isolate neural stem cell populations and study their potential for maintenance, differentiation and regeneration [supported by the Max Planck Society]
Email:
Dr Dominik Herzog
Postdoctoral fellow
Addresses the molecular function of Rho GTPases in the control of neural stem cell differentiation and in the formation of brain tumours. This involves using genetic tools to manipulate neural stem cells and study their maintenance, differentiation and tumour formation [supported by Landesstiftung Baden-Württemberg, Germany]
Email:
Mr Sebastian Lugert
Postgraduate Student
Studies the glial brain tumour (glioma) niche at the molecular level using genetic mechanisms to study gene function and signalling pathways [supported by the German Research Council]
Email:
Miss Miriam Vogt
Postgraduate Student
Studies the molecular mechanisms of the RNA binding protein TDP43, a target for mutations in human neurodegenerative diseases and regulator of neural stem cell differentiation. [supported by the German Research Council]
Email:
Mr Robert Beattie
Postgraduate Student
Is analysing a novel niche signalling mechanisms that controls neural stem cell differentiation.
Email: r.beattie@sheffield.ac.uk
Mr Frank Sager
Technical Assistant and lab co-ordinator
Manages the day-to-day running of the lab and the technical aspects of molecular cell biology and histology.
Email: F.Sager@sheffield.ac.uk
