Stem Cells & Cancer
Prof Peter Andrews - Principle Investigator
The appearance of genetically abnormal cells aising from pluripotent stem cells in culture offers a unique model to study the initiation and progression of cancer cells. These models will allow the identification of critical genes which are responsible for the cancer-like properties of cells and may lead to novel strategies and therapies for treatment.
Group members:
Ivana Barbaric, Ph.D. BSc. Research Fellow
Investigating the mechanisms by which culture adapted human ES cells may gain a growth advantage, and also the use of high content screening to identify agents that influence the growth and behaviour of human ES cells.
Email: I.Barbaric@sheffield.ac.uk
Daniel Coca, Ph.D., MEng. Senior Research Fellow
The use of non-linear dynamical modelling to study meta-stability and lineage decisions in pluripotent stem cells.
Email: D.Coca@sheffield.ac.uk
Joelle Desmarais, Ph.D. BSc. Research Fellow
Analysing the mechanisms that control DNA repair and influence the genetic stability of human ES cells, in collaboration with Professor Mark Meuth of the Sheffield Institute of Cancer Studies.
Email: j.desmarais@sheffield.ac.uk
Nick Childs, International Stem Cell Initiative Coordinator
Administrator for the International Stem Cell Initiative.
Email: N.Childs@sheffield.ac.uk
Andrew Gaffney, BSc. Postgraduate Student
Developing a model for Ewing’s sarcoma using iPS cells.
Email: gsp08apg@sheffield.ac.uk
Paul Gokhale, Ph.D. BSc. Research Fellow
Investigating the mechanisms that determine the alternative fates of self renewal, death or differentiation in human ES and EC cells, and the mechanisms that control lineage choice upon differentiation.
Email: P.Gokhale@sheffield.ac.uk
David Harley, BSc. Postgraduate Student
Investigating the role of the DLK1 in the survival, proliferation and differentiation of human ES cells.
Email: D.J.Harley@sheffield.ac.uk
Neil Harrison Ph.D. B.Sc. Research Fellow
Investigating the genetic changes that stem cells may undergo in culture. An understanding of this process is important for devising methods to ensure genetic stability of cells used in therapy and can be used as a model of the development of cancers.
Email: N.J.Harrison@sheffield.ac.uk
Jamie Jackson, B.Sc, Ph.D. Research Assistant
iPS cell derivation and chracteriation.
Email:
Mark Jones Ph.D. B.Sc. Manager of Flow Cytometry Facility
Runs the Centre’s flow cytometry facility and trains staff and students. Flow cytometry is an essential tool for stem cell biology. Our facility allows the use to rapidly analyse the composition of cell cultures and to isolate cells for further culture and detailed investigations.
Email: Mark.Jones@sheffield.ac.uk
Christian Unger, Ph.D. Research Fellow
Developing methods to produce new human induced pluripotent stem (iPS) cells particularly from cancer cells in order to establish in vitro models of cancer development.
Email: C.Unger@sheffield.ac.uk
